ALOPECIA AND JANUS KINASE ENZYMES
Researchers have identified the specific immune cells and primary inflammatory signalling pathways responsible for infiltrating the hair follicle in alopecia areata, forcing them into a dormant state.
Experiments with mouse and human hair follicles showed that oral and topical drugs inhibit the Janus kinase (JAK) family of enzymes.
The JAK family is a suppressor of signalling molecules and plays a role in the immune regulation and growth cycle of the hair follicle. When the JAK family of enzymes are inhibited, inflammatory signalling is blocked, and the hair follicle regenerates so hair grows back as normal.