ZINC AND ANDROGENIC ALOPECIA
Androgenic alopecia is type of hair loss that affects the front and top pf scalp. Male pattern hair loss generally presents as a receding hairline and / or loss of hair on the scalp. Female pattern hair loss generally appears as a widening of the parting, a recession at the temples or diffuse hair loss.
Androgen dependant hair loss such as androgenic alopecia develops after altered androgen metabolism results in an increase of dihydrotestosterone (DHT) and a decrease of testosterone in the hair follicle. DHT reduces hair growth by enhancing expression and translation of genes that encourage premature entry into catagen phase .
Zinc is important for the function of hydroxysteroid dehydrogenases that convert adrostenediol, dehydroepiandrosterone and androstenedione to testosterone. These hydroxysteroid dehydrogenases also inactivate DHT into adrostenediol lowering the concentration of local DHT .
Zinc also increases local levels of testosterone allowing binding of growth factor to sustain normal hair growth.