FOOD ALLERGY SYMPTOMS AND ALOPECIA AREATA MAY IMPROVE WITH SIMILAR TREATMENT
There are several factors suspected as alopecia areata disease onset triggers. The modulators that are thought to provoke the immune system include viruses, stress, bacterial infection, pathogenic gut bacteria, and diet [1-5].
Alopecia areata has a complex pattern of clinical presentation which indicates multiple contributing pathogenic factors are involved.
These factors come together in a way that induce an autoimmune response that results in hair follicle specifically antigens [6,7].
Alopecia areata and food allergy response are both relieved by antihistamines. Ebastine, an antihistamine, has shown positive results in patients with extensive alopecia areata. Ebastine is a second-generation histamine H1 receptor antagonist that is used to attenuate allergic inflammation. Most pharmacological studies of antihistamines have focused on cellular aspects of allergic responses and immune regulation. Though some clinical observations have suggested favourable effects of antihistamines on alopecia areata.
Nori et al. showed that ebastine suppresses the production of Th2 and pro-inflammatory cytokines and inhibits T cell migration. It is the migration of T-cells to the hair follicle that instigates the immune response in the scalp area. T-cell infiltration was hardly detected in alopecia areata patches of ebastine-treated mice. This observation suggested that ebastine plays some roles in the suppression of the T-cell-mediated immune response in alopecia areata lesions.