As the body needs more than just amino acids derived from collagen to synthesise new collagen, it is imperative you provide your body with the necessary cofactors to build new collagen.
Iron – Iron participates in collagen synthesis though it’s interaction with enzymes involved in the building collagen. Research has shown that removal of iron inhibits prolyl 4-hydroxylase, a key enzyme in collagen synthesis . Thus, iron deficiency or iron deficiency anaemia will affect collagen synthesis.
Vitamin C – Vitamin C plays a crucial role in the maintenance of the normal collagen network by inhibiting the breakdown of collagen and act as an electron donor to enzymes that add a hydroxyl group to lysine and proline.
This hydroxyl addition posttranslationally alters lysine to hydroxylysine and proline hydroxyproline. This hydroxylation process is what allows collagen to assume its three dimensional structure.
Silicon – Biological silicon is shown to stimulate Type I synthesis. Silicon is important for the activation of hydroxylation enzymes neccessary for collagen formation.
Zinc – Increasing zinc intake will stabilise lives of cortisol over time leading to a slower breakdown of collagen. Zinc also plays a reparative role and administration of zinc has been shown to increase collagen accumulation.
Copper – Copper is needed for the activation of lysyl oxidase. Active lysyl oxidase is needed for collagen maturation and enables cross-linking of collagen fibres with other supportive networks .